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1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester

Basic Information

  • CAS No.: 112811-71-9
  • Purity: 99%
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Details

Top quality factory supply 112811-71-9 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester at low price

  • Molecular Formula: C16H15F2NO4
  • Molecular Weight: 323.296
  • Appearance/Colour: Pale yellow solid 
  • Vapor Pressure: 0mmHg at 25°C 
  • Melting Point: 179-181 °C 
  • Refractive Index: 1.578 
  • Boiling Point: 459.695 °C at 760 mmHg 
  • PKA: -2.98±0.40(Predicted) 
  • Flash Point: 231.816 °C 
  • PSA： 57.53000 
  • Density: 1.415 g/cm3 
  • LogP: 2.79990 

1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester(Cas 112811-71-9) Usage

InChI:InChI=1/C16H15F2NO4/c1-3-23-16(21)10-7-19(8-4-5-8)13-9(14(10)20)6-11(17)12(18)15(13)22-2/h6-8H,3-5H2,1-2H3

112811-71-9 Relevant articles

COMPOUNDS TARGETING RNA-BINDING PROTEINS OR RNA-MODIFYING PROTEINS

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, (2021/09/11)

The invention relates to a compound repr...

Gatifloxacin and synthesis method thereof

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Paragraph 0061-0062; 0065-0066; 0069-0070, (2020/03/23)

The invention relates to a gatifloxacin ...

Preparation method of 1-cyclopropyl-6,7-difluoro-8-methoxyfluoroquinolone-3-carboxylate

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, (2020/06/17)

The invention discloses a preparation me...

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112811-71-9 Process route

ethyl 3-(cyclopropylamino)-2-(2,4,5-trifluoro-3-methoxybenzoyl)acrylate
112811-70-8

ethyl 3-(cyclopropylamino)-2-(2,4,5-trifluoro-3-methoxybenzoyl)acrylate

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

Conditions
Conditions Yield
With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 5h;
With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 5h;
627 mg
With potassium carbonate; In dimethyl sulfoxide;
With potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 5h;
With sodiumfluoride; In N,N-dimethyl-formamide; for 5h;
With potassium fluoride; tetrabutylammomium bromide; In N,N-dimethyl-formamide; at 120 ℃; for 6h; under 1125.11 Torr; Reagent/catalyst; Temperature; Pressure; Solvent;
ethyl α(Z)-[(diethylamino)methylene]-2,4,5-trifluoro-3-methoxy-β-oxo-benzenepropanoate

ethyl α(Z)-[(diethylamino)methylene]-2,4,5-trifluoro-3-methoxy-β-oxo-benzenepropanoate

Cyclopropylamine
765-30-0

Cyclopropylamine

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
112811-71-9

ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

Conditions
Conditions Yield
ethyl α(Z)-[(diethylamino)methylene]-2,4,5-trifluoro-3-methoxy-β-oxo-benzenepropanoate; Cyclopropylamine; In diethyl ether; ethanol; at 20 ℃; for 3h;
With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 5h;
82%

112811-71-9 Upstream products

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    ethyl 3-(cyclopropylamino)-2-(2,4,5-trifluoro-3-methoxybenzoyl)acrylate

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    ethyl α(E)-[(diethylamino)methylene]-2,4,5-trifluoro-3-methoxy-β-oxo-benzenepropanoate

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112811-71-9 Downstream products

  • 112811-72-0
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    1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

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    1-cyclopropyl-6,7-difluoro-8-hydroxy-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

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    139693-52-0

    1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid-O3 ,O4 (bis(acyloxy-O)) borate

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    C23 H23 FN2 O4

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