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2'-Deoxy-L-thymidine

Basic Information

  • CAS No.: 3424-98-4
  • Purity: 99%
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Quality products?make an important contribution to long-term revenue and profitability. Factory Supply industrial standard 2'-Deoxy-L-thymidine 3424-98-4 In Stock

1.What is the 2'-Deoxy-L-thymidine ?

Telbivudine(Tyzeka, Sebivo) is an antiviral drug used in the treatment of hepatitis B infection. Clinical trials have shown it to be significantly more effective than lamivudine or adefovir, and less likely to cause resistance. Telbivudine is a synthetic

C<sub>10</sub>H<sub>13</sub>BrN<sub>2</sub>O<sub>5</sub>

C10 H13 BrN2 O5

C<sub>10</sub>H<sub>14</sub>N<sub>2</sub>O<sub>5</sub>
50-89-5,3424-98-4,4449-43-8,4781-17-3,16053-52-4,36646-86-3,39131-66-3,68224-82-8,128112-70-9,131682-41-2,137121-87-0,28854-96-8,3545-96-8,50-88-4

C10 H14 N2 O5

Conditions
Conditions Yield
With hydrogen; nickel; In water; for 2 - 3h; under 1125.11 Torr;
80%
With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; for 0.5h; Heating / reflux;
3',5'-di-O-acetyl-β-L-thymidine
433733-94-9

3',5'-di-O-acetyl-β-L-thymidine

C<sub>10</sub>H<sub>14</sub>N<sub>2</sub>O<sub>5</sub>
50-89-5,3424-98-4,4449-43-8,4781-17-3,16053-52-4,36646-86-3,39131-66-3,68224-82-8,128112-70-9,131682-41-2,137121-87-0,28854-96-8,3545-96-8,50-88-4

C10 H14 N2 O5

Conditions
Conditions Yield
With ammonia; In methanol; at 6 ℃; for 72h;
93.4%
With methanol; ammonia; at 50 ℃; for 12h; Large scale;
89%
3',5'-di-O-acetyl-β-L-thymidine; With sodium hydroxide; ethanol; water; for 48h; Heating / reflux;
With water; acetic acid; In ethanol; at 76 ℃; for 0.5h;

2.What is the CAS number for 2'-Deoxy-L-thymidine ?

The CAS number of 2'-Deoxy-L-thymidine is 3424-98-4.

More information of 2'-Deoxy-L-thymidine 3424-98-4 are:

CAS?Number

3424-98-4

Density

1.452 g/cm3

Melting Point

188-190 °C

HS CODE

29349990

PSA

104.55000

LogP

-1.51430

Pka

9.55±0.10(Predicted)

3.What are another words for 2'-Deoxy-L-thymidine ?

Synonyms?for?2'-Deoxy-L-thymidine 3424-98-4:Thymine,1-(2-deoxy-b-L-erythro-pentofuranosyl)-(7CI,8CI);Epavudine;L-Thymidine;NV 02B;Telbivudine;b-L-Thymidine;

4.What is the molecular formula of 2'-Deoxy-L-thymidine?

The chemical formula of ?2'-Deoxy-L-thymidine is?C10 H14 N2 O5 which containing 10 Carbon atoms,14 Hydrogen atoms,2 Nitrogen atoms and 5 Oxygen atoms,and the molecular weight of??2'-Deoxy-L-thymidine?is 242.232.

5.What is 2'-Deoxy-L-thymidine (3424-98-4) used for?

Telbivudine is a b-L-thymidine nucleoside analog launched for the once-daily oral treatment of chronic hepatitis B virus (HBV) infection. It is the fourth nucleoside or nucleotide analog to be marketed for this indication. The previous drugs from this class include lamivudine, a deoxythiacytosine analog, adefovir, a nucleotide analog, and entecavir, a guanosine analog. Adefovir, entecavir, and telbivudine are specifically indicated for HBV, whereas lamivudine is indicated for both HBV and HIV infections. Telbivudine is efficiently phosphorylated by cellular kinases to the active triphosphate derivative, which inhibits HBV DNA polymerase by competing with the natural substrate, thymidine- 5’-triphosphate.

Relevant articles related to 2'-Deoxy-L-thymidine:

Article

Source

Synthesis method of beta-thymidine

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Paragraph 0049; 0050, (2017/08/14)

METHODS FOR THE TREATMENT OF HEPATITIS B AND HEPATITIS D VIRUS INFECTIONS

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, (2016/02/26)

6.Buy 2'-Deoxy-L-thymidine with the best price .

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