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isolysergic acid

Basic Information

  • CAS No.: 478-95-5
  • Purity: 99%
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Details

Good factory supply good isolysergic acid 478-95-5

  • Molecular Formula: C16H16 N2 O2
  • Molecular Weight: 268.315
  • Vapor Pressure: 2.51E-12mmHg at 25°C 
  • Melting Point: 218° (dec) 
  • Refractive Index: 1.6240 (estimate) 
  • Boiling Point: 536.2°C at 760 mmHg 
  • PKA: 3.44, pKb 8.61(at 25℃) 
  • Flash Point: 278.1°C 
  • PSA： 56.33000 
  • Density: 1.39g/cm3 
  • LogP: 2.06010 

isolysergic acid(Cas 478-95-5) Usage

Purification Methods

It crystallises from water as the dihydrate. The methyl ester has m 172-174o (from MeOH or *C6H6) and [] 20 +179o (c 0.5 CHCl3). [Smith & Timmis J Chem Soc 1440 1936, Craig et al. JBiochem 125 289 1938, Stenlake J Chem Soc 1626 1955, Leemann & Fabbri Helv Chim Acta 4 2696 1959, Beilstein 25 III/IV 935.]

InChI:InChI=1/C16H16N2O2/c1-18-8-10(16(19)20)5-12-11-3-2-4-13-15(11)9(7-17-13)6-14(12)18/h2-5,7,10,14,17H,6,8H2,1H3,(H,19,20)

478-95-5 Relevant articles

PROCESS FOR THE MANUFACTURE OF LYSERGIC ACID

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Page/Page column 6-7, (2008/06/13)

Lysergic acid is formed in high yields a...

Enantioefficient synthesis of α-ergocryptine: First direct synthesis of (+)-lysergic acid

Moldvai, Istvan,Temesvari-Major, Eszter,Incze, Maria,Szentirmay, Eva,Gacs-Baitz, Eszter,Szantay, Csaba

, p. 5993 - 6000 (2007/10/03)

The first direct synthesis of (+)-lyserg...

478-95-5 Process route

lysergic acid sulfate
88133-12-4

lysergic acid sulfate

6-methyl-9,10-didehydro-ergoline-8-carboxylic acid
478-95-5

6-methyl-9,10-didehydro-ergoline-8-carboxylic acid

D-lysergic acid
82-58-6

D-lysergic acid

Conditions
Conditions Yield
With ammonia; In methanol; water; Product distribution / selectivity;
<i>N</i>-[(7-methyl-6,6a,7,8-tetrahydro-4<i>H</i>-indolo[4,3-<i>fg</i>]quinolin-9-ylidene)-(toluene-4-sulfonyl)-methyl]-formamide
764710-82-9

N -[(7-methyl-6,6a,7,8-tetrahydro-4H -indolo[4,3-fg ]quinolin-9-ylidene)-(toluene-4-sulfonyl)-methyl]-formamide

6-methyl-9,10-didehydro-ergoline-8-carboxylic acid
478-95-5

6-methyl-9,10-didehydro-ergoline-8-carboxylic acid

D-lysergic acid
82-58-6

D-lysergic acid

Conditions
Conditions Yield
With hydrogenchloride; for 0.5h; Title compound not separated from byproducts; Heating;

478-95-5 Upstream products

  • 764710-82-9
    764710-82-9

    N -[(7-methyl-6,6a,7,8-tetrahydro-4H -indolo[4,3-fg ]quinolin-9-ylidene)-(toluene-4-sulfonyl)-methyl]-formamide

  • 88133-12-4
    88133-12-4

    lysergic acid sulfate

478-95-5 Downstream products

  • 82-58-6
    82-58-6

    D-lysergic acid

  • 1268723-18-7
    1268723-18-7

    C59 H81 N13 O11 S

  • 1268723-30-3
    1268723-30-3

    C62 H79 FN12 O10 S

  • 1268723-11-0
    1268723-11-0

    C57 H78 N12 O10 S

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